Over the past decade, multiple landmark trials have refined understanding of respiratory disease management, challenged long-standing practices, and introduced new therapeutic paradigms. Familiarity with these studies can improve clinical reasoning and interdisciplinary communication.
 

1. TORCH Trial (COPD)

The TORCH trial evaluated the effects of combined inhaled corticosteroids and long-acting beta-agonists on mortality in COPD patients.

Pending Write-up

2. FLAME Trial (COPD Exacerbations)

Pending Write-up

3. PANTHER-IPF Trial (Interstitial Lung Disease)

Pending Write-up

4. ARDSNet Low Tidal Volume Trial

Pending Write-up

5. INCREASE Trial (Pulmonary Hypertension Associated with ILD)

Pending Write-up

References

1. Calverley PMA, et al. N Engl J Med. 2007;356:775–789.

2. Wedzicha JA, et al. N Engl J Med. 2016;374:2222–2234.

3. Raghu G, et al. N Engl J Med. 2012;366:1968–1977.

4. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342:1301–1308.

5. Waxman AB, et al. N Engl J Med. 2021;384:325–334.